|Noah Webster's Dictionary|
(a.) Full of despite; expressing malice or contemptuous hate; malicious.
Int. Standard Bible Encyclopedia
de-spit', de-spit'-fool: "Despite" is from Latin despectus, "a looking down upon." As a noun (= "contempt") it is now generally used in its shortened form, "spite," while the longer form is used as a preposition (= "in spite of"). In English Versions of the Bible it is always a noun. In the Old Testament it translates Hebrew she'aT, in Ezekiel 25:6, and in the Revised Version (British and American) Ezekiel 25:15; Ezekiel 36:5 ("with despite of soul"). In Hebrews 10:29 ("hath done despite unto the Spirit of grace") it stands for Greek enubrizo, "to treat with contempt."
The adjective "despiteful" occurs in the King James Version Ezekiel 25:15; Ezekiel 36:5; Sirach 31:31 ("despiteful words," the Revised Version (British and American) "a word of reproach"); Romans 1:30 (the Revised Version (British and American) "insolent" = Greek hubristes, from huper, "above"; compare English "uppish").
D. Miall Edwards
Despiteful (3 Occurrences)
Romans 1:30 Backbiters, haters of God, despiteful, proud, boasters, inventors of evil things, disobedient to parents, (KJV WBS)
Ezekiel 25:15 Thus saith the Lord GOD; Because the Philistines have dealt by revenge, and have taken vengeance with a despiteful heart, to destroy it for the old hatred; (KJV WBS)
Ezekiel 36:5 Therefore thus saith the Lord GOD; Surely in the fire of my jealousy have I spoken against the residue of the heathen, and against all Idumea, which have appointed my land into their possession with the joy of all their heart, with despiteful minds, to cast it out for a prey. (KJV WBS)