Noah Webster's Dictionary 1. (v. t.) To annoy; to inflame; to render null and void. 2. (v. t.) To increase the action or violence of; to heighten excitement in; to intensify; to stimulate. 3. (v. t.) To excite anger or displeasure in; to provoke; to tease; to exasperate; to annoy; to vex; as, the insolence of a tyrant irritates his subjects. 4. (v. t.) To produce irritation in; to stimulate; to cause to contract. See Irritation, n., 2. 5. (n.) To make morbidly excitable, or oversensitive; to fret; as, the skin is irritated by friction; to irritate a wound by a coarse bandage. 6. (a.) Excited; heightened.

Multi-Version Concordance Irritate (2 Occurrences) Ephesians 6:4 And you, fathers, do not irritate your children, but bring them up tenderly with true Christian training and advice. (WEY) 1 Samuel 1:6 Her rival provoked her sore, to make her fret, because Yahweh had shut up her womb. (See NAS RSV NIV)