|Noah Webster's Dictionary|
(n.) Importance; relevance.
Significance (2 Occurrences)
Luke 2:50 But they did not understand the significance of these words. (WEY)
Revelation 8:13 Then I looked, and I heard a solitary eagle crying in a loud voice, as it flew across the sky, "Alas, alas, alas, for the inhabitants of the earth, because of the significance of the remaining trumpets which the three angels are about to blow!" (WEY)